114沟槽法兰:益心通脉汤治疗冠心病心绞痛血瘀证临床研究
【摘要】 :目的 观察益心通脉汤治疗冠心病心绞痛血瘀证的临床疗效,并探讨其作用机制。方法 将60例冠心病心绞痛血瘀证患者随机分为2组。治疗组30例,
【关键词】 益心通脉汤 冠心病心绞痛 血瘀证
Abstract:Objective To observe the clinical effects of Yixin Tongmai Decoction in treating angina pectoris in CHD (blood stasis syndrome) and explore its mechanism. Methods Sixty patients were randomized into two groups. The treatment group (30 cases) and the contrastive group (30 cases) were respectively given Yixin Tongmai Decoction and Danshen Injection. The clinical and ECG effect, the indexes of hemorrheology were observed. Result Effective rate of treatment group was 90.00%, significantly higher than 70.00% of contrastive group (P<0.05). Therapy of the treatment group has the effects of reducing blood viscosity and improving hemorrheological properties (P<0.05). Both two groups had the alteration of plasma endothelin (ET) level and thromboxan B2 (TXB2) significantly lowering (P<0.05, P<0.01) and 6-keto-prostacyclin (6-keto-PGF1α) rising, and treatment group was more remarkably alterated than contrastive group (P<0.05). Conclusion Yixin Tongmai Decoction has curative effect on symptoms of angina pectoris in CHD (blood stasis syndrome), relieves heart muscle ischemia, meanwhile improves hemorrheological properties.
Key words:Yixin Tongmai Decoction;angina pectoris in CHD;blood stasis syndrome
冠心病发病机制为冠状动脉粥样硬化,管腔狭窄或闭塞,或者冠状动脉痉挛,或者冠脉内粥样硬化斑块破裂出血,胶原纤维和胶质核暴露,诱发局部血小板聚集及凝血系统激活等一系列反应,以致心肌缺血而
1 资料与方法
1.1
符合诊断的60例患者均为本院心血管内科住院及门诊患者,随机分为治疗组30例和对照组30例。治疗组男性20例,女性10例;年龄45~71岁,平均(48.75±13.10)岁;病程1~6年,平均(4.34±1.25)年。对照组男性19例,女性11例;年龄48~70岁,平均(46.86±13.05)岁;病程1~7年,平均(4.68±1.44)年。2组资料在性别、年龄、病程等
1.2 治疗方法
治疗组采用益心通脉汤治疗。药物组成:黄芪25 g,太子参15 g,丹参30 g,沉香6 g,砂仁6 g,五灵脂10 g,蒲黄(包煎)10 g,赤芍药10 g,炙甘草6 g。由本院
对照组采用复方丹参注射液(上海
2组均1周为1个疗程,治疗3个疗程后评定疗效。视病情
1.3 观察指标及方法
1.3.1 心电图
试验前后各行12导联心电图检查1次,受试者有胸痛不适发作随时检查,静息心电图用日产心电图机(型号为ECG-6511)记录,以NST和∑ST表示用药前、后心电图缺血
1.3.2 血液流变学指标
清晨空腹
1.4 临床疗效判定标准
疗效评定标准参照《中药新药临床
1.5 统计学方法
所有数据以—x±s表示,计数资料用χ2检验,计量资料用t检验。采用SPSS12.0统计软件
2 结果
(见表1~表4)表1 2组患者临床疗效
3
现代医学