硝酸甘油 50mg + NS 40ml 0.6ml/h (10ug/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝 普 钠 50mg + NS 50ml 0.6ml/h (10ug/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴胺 200mg + NS 30ml 4ml/h (5ug/kg/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴酚丁胺 200mg + NS 30ml 4ml/h (5ug/kg/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
去甲肾上腺素 50mg + NS 25 mL 1.5ml/h (0.5ug/kg/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
胰岛素 50u +NS 50ml 5ml/h (0.1u/kg/h kg=50)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
阿端（哌库溴铵） 0.08mg-0.1mg/kg 4mg-5mg 肾功能不全不超过0.04mg/kg 2mgKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
仙林(维库溴铵) 70-100ug/kg 3.5-5mg/h (kg=50)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
咪唑安定 15mg + NS 15 ml 2ml/h (2mg/h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
施他宁 3mg + NS 50ml 4.1ml/h (250ug/h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
吗啡 10mg + NS 9mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
可达龙（胺碘酮） 首剂150 mg + NS 20 mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
维持 300 mg + NS 44ml 小于等于6 ml（35mg/h）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
异丙酚 首剂 40mg 维持 40mg/hKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
尼莫同 起始2小时 1mg/h (>70kg) 或 0.5mg/h(<50kg)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
可耐受者2小时后 2mg/hKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
氨茶碱 起始 250mg+ NS 40ml (30min内)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
维持 500mg+NS 50ml (5ml/h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
利尿合剂 5%葡萄糖 250ml +多巴胺 20mg+立其丁 5-10mg+速尿 80mgKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
仙林（维库溴铵） 首剂 0.08-0.1mg/kg 补充 0.03---0.05mg/kgKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
地高辛 首剂 1-1.5mg/d 维持量 0.25-0.5mg/dKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴酚丁胺 20-40mg+100mlGS(40---120mg/d) 2.5-10ug/kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
利多卡因首剂 50mg iv 无效 100mg /5-10min (<=500-800mg)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
维持 400mg +GS 500ml (<=1000-1500mg/d)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
胺碘酮 首剂 5-10mg/kg iv 维持 300mg ivgtt <=30minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
去甲肾上腺素 首剂 2mg/次 8-12ug/min 维持 2---4ug/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
阿拉明0.015-0.1g + NS 500ml ( 0.2---0.4mg/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
常用药物输注计算Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
药名 微泵药物浓度配制 数字显示 输入剂量 常用剂量 Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
（mg/50ml） (ml/h) Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴胺 体重（kg）×3 1 1.0μg/(kg•min) 5--20μg/(kg•min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝普钠 体重（kg）×3 1 1.0μg/(kg•min) 0.5--8μg/(kg•min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝酸甘油 体重（kg）×0.3 0. 1μg/(kg•min) 1--5μg/(kg•min)最大剂量10μg/(kg•min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴酚丁胺 体重（kg）×3 1 1.0μg/(kg•min) 5--20μg/(kg•min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肾上腺素 体重（kg）×0.03 1 0.01μg/(kg•min) 0.01—0.2μg/(kg•min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
以上用药仅供参考，具体用药视病人情况而定。 Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
常用药物用量配法算Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴胺：（公斤体重×3）mg 稀释至50ml 如泵速为1ml/h,泵入量为1μg/kg/min ,常用剂量1－20μg/kg/min；起始剂量5μg/kg/min；Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴酚丁胺：配法同多巴胺,常用剂量1－20μg/kg/min，起始剂量1μg/kg/min；Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝普钠： 5%GS50ml+硝普钠50mg,即1mg/ml(1000μg/ml)，常用剂量10－200μg/min或0.1－2μg/kg/min,起始剂量5－10μg/min(0.3-0.6ml/h)。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝酸甘油：（公斤体重×0.3）mg 稀释至50ml 如泵速为1ml/h,泵入量为0.1μg/kg/min 或：NS44ml+硝酸甘油30mg,即0.6mg/ml(600μg/ml)，常用剂量10－200μg/min或0.1－2μg/kg/min，起始剂量5－10μg/min（0.5－1ml/h）。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
去甲肾上腺素：（公斤体重×0.3）mg 稀释至50ml 如泵速为1ml/h,泵入量为0.1μg/kg/min常用剂量0.1－2μg/kg/min，起始剂量0.1μg/kg/min（应经中心静脉使用去甲肾上腺素）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肾上腺素：配法同去甲肾上腺素, 起始剂量为0.1μg/kg/min，常用剂量为0.1－1μg/kg/min（尽可能经中心静脉用药）严重低血压及过敏性休克0.3－0.5mg ih或ivKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
异丙肾上腺素：（公斤体重×0.03）mg 稀释至50ml 如泵速为1ml/h,泵入量为0.01μg/kg/min起始剂量0.01μg/kg/min，以目标心率为终点。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
胺碘酮：胺碘酮450mg用5％葡萄糖稀释到45ml,即10mg/ml，150mg iv bolus(10分钟)，60mg/h×6h,30mg/h×18h,20mg/h维持3天，24小时总量不超过1.2gKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
心律平：规格70mg/20ml 70mg用5％葡萄糖液稀释到50ml,iv bolus(10分钟)，密切观察心率及心律，室速或室上速转复后立即停止注射。必要时20分钟后可重复，总量不超过210mg。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肝素：肝素1支（12500u）加NS至12.5ml,配制成1000U/ml，肝素化时：75U/kg iv bolus,继以18U/kg?h静脉泵入,调整剂量使aPTT-R维持在1.5－2.5。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
吗啡：配制成1㎎/ml(20㎎/20ml,或50mg/50ml),5mg iv bolus,继以3mg/h泵入，<1mg/kg。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
常用静脉泵入药物的配制及应用方法（供参考）立其丁：NS45ml+立其丁50mg配制成1mg/ml（1000μg/ml）,常用剂量300-500μg/min，起始剂量为100μg/min静脉泵入。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
利多卡因：抽取原液5支（200mg/10ml?支）即20 mg/ml，首剂1.5mg/kg iv bolus,无效可每隔8分钟重复0.5mg/kg直到总量达3mg/kg,复律成功后2－4mg/min维持。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
垂体后叶素：NS30ml+垂体后叶素60U，即2 U/ml,消化道出血常用剂量0.2－0.4 U/min；咯血常用剂量0.1 U/min；尿崩症患者根据尿量调整，起始剂量0.1－0.2 U/min；感染性休克顽固性低血压患者，常用剂量为0.01－0.04U/min。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
施他宁：配制成250μg/ml,先给负荷量250μg iv bolus,然后以250μg/h静脉泵入。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
安定：先10mg iv bolus,继以5mg/h泵入，最大100mg/d.Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
德巴金（注射用丙戊酸钠）：规格400mg/支 配制成10mg/ml,首剂400mg(15mg/kg), iv bolus,大于5分钟，维持60mg/h（1－2mg/kg/h）.Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
尼莫通：规格10mg/50ml 起始量0.2mg/h(1ml/h),根据血压情况依次递增至全量2mg/h，维持到蛛网膜下腔出血后的10－14天。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
氨茶碱：0.5 稀释至50ml配制成10mg/ml，成人负荷剂量5mg/kg, iv bolus，速度＜25mg/min.(一般成人氨茶碱0.25，静注15分钟即可)维持剂量0.5－0.7mg/kg/h。可从20mg/h(2ml/h)开始。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
胰岛素：配制成1U/ml,起始速度1U/h,根据血糖调整。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
阿曲库铵：首剂 0.3-0.5mg/kg (标准速度9-10ug/kg/min), iv,再5-9ug/kg/min维持Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硫酸镁：负荷剂量25％硫酸镁10ml稀释1倍，iv bolus.维持剂量：25％硫酸镁4.0加入5％葡萄糖溶液或生理盐水250ml，1-3ml/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
维库溴铵：首剂 0.075mg/kg iv,再0.075mg/kg/h维持Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
芬太尼: 先负荷4--20u/kg,再维持2-10u/(kg.h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
奥曲肽: 初始量0.1mg iv(>5min),再维持0.025-0.05mg/hKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
咪达唑仑: 先iv 2-3mg/kg,再维持0.05mg/(kg.h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
双异丙酚: 0.3-0.4mg/(kg.h)泵入,规格200mg/20mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
依托咪酯: 10ug/(kg.min) 泵入 规格20mg/10mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
1.酚妥拉明(立其丁)：为α受体阻断剂，以扩张小动脉为主，静滴以0.1mg/min始，5~10min调整一次量，最大可增至1.5~2.0mg/min，注意测血压以防Bp骤降。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
2.异丙肾上腺素：是β1、β2受体兴奋剂，作用为加强心肌收缩力，加快心率、加快传导速度，以及中等度扩张血管作用，使心肌耗氧量增加，增加心肌应激性，引起心律失常。有冠心病者忌用，因易引起严重的心律失常。剂量为0.1~0.2mg%，成人2~4μg/kg min，(儿童0.05~0.2μg/min),相当于2mg加入5% GS 250ml中10gtt/min。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
3.多巴胺：兴奋α、β受体。一般2~5mg/kg min。如5% GS 250ml含多巴胺80mg，则320μg/ml，相当于5.4μg/kg min，主要兴奋多巴胺受体，内脏血管、肾血管扩张。6~15μg/kg min时，主要兴奋β受体，心肌收缩力增强。(以上浓度2~3ml/min)。还有心输出量增加，而对心率的影响相对较少，较少引起心律失常，对β2的影响较少。若>20mg/kg min以上浓度或4ml/min时，主要兴奋α受体，肾血管收缩。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
4.多巴酚丁胺：为多巴胺的洐生物，常用于心源性休克，具有α、β肾上腺素能作用的拟交感N药物，对心脏正性肌力作用较多巴胺强，能增加心排量和收缩压，降低肺楔压，明显改善心泵功能，对外周血管作用不明显，小剂量有轻度收缩血管效应，较大剂量时有双重效应。常量2.5~10μg/kg min，相当于5% GS 250ml中加入多巴酚丁胺40mg。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
5.去甲肾上腺素：α受体兴奋剂，血管收缩强，一般用作上消化道出血口服。必要升压时静滴，0.5~2.0mg%，4~8μg/min。即5% GS 250ml加入去甲肾2mg，相当8μg/ml。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
6.硝普钠：动-静脉扩张剂，12.5~25μg/min始，5~10min调整一次量，相当于5% GS 500ml加入硝普钠50mg，即100μg/ml，应用5gtt/min。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
7.硝酸甘油：扩张小静脉，降低回心血量，使LVEDP及肺血管压降低。10μg/min始，在5% GS 250ml加入硝甘5mg，10gtt/min。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
常用抢救药物泵入量设置方法Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝酸甘油 5mg/mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
50mg+NS40ml /iv泵入0.6ml/h(10ug/min),Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
5mg+5%GS500ml iv drip 1ml/min(10ug/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
可用到200ug/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
1. 异舒吉 50mg/50mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
50mg原液（50ml）/iv 泵入5ml/h(5mg/h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
50mg+5%GS500ml iv drip(5mg/h 50ml/h 13滴/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
2. 硝普钠 50mg/支Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
50 mg+5%GS 50ml /iv泵入0.6ml/h(10ug/min起始),Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
可用到200-300ug/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
4.多巴胺，多巴酚丁胺 20mg/2mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
(Kg×3)mg加NS至50ml/ iv 泵入,1ml/h 相当于1ug/Kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
如：体重60Kg的患者，用量为： 5ug/Kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
180mg+NS32ml / iv 泵入,5ml/hKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
60mg+5%GS500ml iv drip 1ml/min(2ug/Kg/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
500mg （原液）/ iv 泵入 1ml/hr约等于2.8ug/kg/min(60kg)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
5. 压宁定 50mg/10mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
25mg+NS20ml 慢推可用到400ug/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
250ml原液（50ml）/iv 泵入1.2ml/h(100ug/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
100mg+5%GS500ml iv drip 1ml/min(200ug/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
6.酚妥拉明（瑞支停） 10mg/2mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
50mg+40ml/ iv 泵入2ml/h(2mg/h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
7.吗啡 10mg/1mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
50mg + NS 45 ml/iv 泵入,1-6 ml/h(1-6 mg/h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
8.去甲肾上腺素 2 mg/1mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
(Kg×0.3)mg加NS至50ml/ iv 泵入,1ml/h 相当于0.1ug/Kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
如：体重60Kg的患者，用量为： 0.5ug/Kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
18mg+NS 41 ml / iv 泵入,5ml/hKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
常用剂量为0.1-2.0 ug/kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
报告最大剂量可达10.0 mcg/kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
8.肾上腺素 1 mg/mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
(Kg×0.3)mg加NS至50ml/ iv 泵入,1ml/h 相当于0.1ug/Kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
如：体重60Kg的患者，用量为： 0.5ug/Kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
18mg+NS 32 ml / iv 泵入, 5 ml/hKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
常用剂量为0.1 - 2.0 ug/kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
报告最大剂量可达10.0 mcg/kg/minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
9.异丙肾上腺素 1mg/2mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
1mg+5%GS500ml iv drip 7滴/min(1ug/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
3mg+NS44ml /iv泵入1ml/h(1ug/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
10.利多卡因 400mg/2%20mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
1000mg/ iv 泵入 6ml/h (2mg/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
1000mg+5%GS500ml iv drip 1-2ml/min(2-4mg/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
11.垂体后叶素 6U/1ml 12U-18U入壶Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
用于消化道出血: 300U/iv泵入2-4ml/h(0.2-0.4U/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
102U+5%GS500ml iv dripKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
1-2ml/min(0.2-0.4U/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
咯血:54U+5%GS500ml iv drip 1ml/min(0.1U/min)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
12.思他宁 3mg/支 250 ug/支Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
250ug入壶Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
3mg+NS48ml /iv泵入4ml/h(250ug/h)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
13.肝素 100mg/12500U/2ml/支Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
12500U+NS48ml /iv泵入2ml/h(500U/h) 根据APTT调整Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
按照U/kg/hr记录用量Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
14.艾司洛尔 200mg/5ml →100mg/10mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
5mg/Kg iv 入壶Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
500mg/ iv 泵入 18ml/h(0.05mg/Kg/min, 60Kg, 100mg/10ml)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
剂量可加大,首剂也加大Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
15.安定 50ml纯安定（250mg） 5mg/mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
16.善宁 500ug/支Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
NS 50+0.5Mg iv 泵入 5ml/H （5ug/hr）最大50ug/hrKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
17.乌拉地尔（压宁定） 25mg/5ml/支 控制高血压Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
先缓慢静注10-50mg，监测血压变化。效果在5分钟内显示后 维持降压效果：100mg稀释成50ml（NS，5-10%GS，5%果糖均可）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
最大药物浓度为4mg/mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
初始输入速度为2mg/min，维持给药9mg/hKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
若将250mg乌拉地尔溶解在500ml液体里则1mg乌拉地尔相当于44滴或2.2ml输入液Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
18.地尔硫卓（合贝爽） 10mg 或50mg /支 冷冻干燥品Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
将10mg或50mg用5ml以上的NS或GS.溶解Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
室上速: 10mg 配成10ml缓慢静推 单次静注,可根据年龄和症状增减.Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
高血压急症:5-15ug/kg/min 静脉点滴,当血压降至目标值后,Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
边监测边调整速度Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
不稳定心绞痛:1-5ug/kg/min,小剂量开始,最大用量5ug/kg/min.Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
19．硝酸异山梨酯（爱倍） 5ml：5mg ；10ml：10mgKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
25ml+500ml NS或5%GS=50ug/mlaKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
开始剂量：30ug/min，观察0.5-1小时,如无不良反应可加倍.Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
20.RI 400u/10mlKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
80u+NS38ml iv 泵入 1ml/hr=2u/hrKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
21.洛赛克Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
8mg/hr 泵入Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
22.氨茶碱Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
0.5+NS30ml iv 泵入 1.5-2.5ml/hr 日总量0.75-1.0Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
血管活性药物的应用Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
心血管活动的生理调节Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
自主神经系统（交感、副交感）快速、短期内的调节：Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
①心血管中枢Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
②周围神经支配（去甲肾上腺素）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
体液调节Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
①肾上腺髓质（肾上腺素）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
②血管内皮生成的血管活性物质（前列环素、NO）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
局部血流调节Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
动脉血压的长期调节Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
用药分类Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
1 拟传出神经系统类药物：Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
儿茶酚胺类（肾上腺素能受体激动剂）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
-肾上腺素能受体阻断剂Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
-肾上腺素能受体阻断剂Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
2 直接作用于心血管平滑肌系统的药物：Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
磷酸二酯酶抑制剂Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
洋地黄类Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝酸酯类Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
小儿心泵功能的特点Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
心肌细胞直径小，收缩成分少，故心室收缩和舒张顺应性均差--相对来说，每搏储备力差，故更加依赖心率储备。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
心肌为未成熟心肌，与成熟心肌的差异是肌浆网与T小管发育较差，对钙的储备及释放能力相对弱--对外源性钙依赖，但缺血期更易引起钙中介的损伤。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
小儿心血管系统迷走张力性高--对儿茶酚胺类药物较成人更为依赖。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
ICU用药特点： 起效快、半衰期短、效果确切Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
PICU最常用心血管活性药物Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
强心甙类Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
儿茶酚胺类Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
磷酸二酯酶抑制剂Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝酸酯类Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴胺（Dopamine）药理作用：Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
对不同受体兴奋程度呈明显的剂量依赖性。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
小剂量（＜5ug/kg.min）--多巴胺R--内脏血管扩张（冠状动脉、肾脏血管、肠系膜血管、脑血管）；Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
中等剂量（5～10ug/kg.min）--1-R为主--促进去甲肾上腺素的释放--增加心肌收缩力、HR、CO；Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
大剂量（＞ 20ug/kg.min）--1-R为主--外周血管收缩、增加外周阻力和心脏后负荷。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴胺（Dopamine）在PICU：起效快，除少数简单畸形，绝大多数患儿从术中复跳时就开始应用。应用小~中等剂量（ 5～10ug/kg.min），安全的心脏辅助作用。同时有一定的利尿效果。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴酚丁胺（Dobutamine）药理作用：对1-R有相对的选择性，明显的增强心肌收缩力的作用。对α、β2及多巴胺受体作用微弱。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多巴酚丁胺在PICUKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
强心作用，5～15ug/kg.minKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
国内一般与多巴胺联合用药，很少单独应用Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
PICU观察其增加HR也较明显，心率慢患儿应用后，稳定循环效果明显。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肾上腺素adrenaline（epinephrine）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
兼有α、β效用，α＞β，临床作用较复杂。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
心脏：1-R作用，强效的心脏兴奋剂。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
血管：引起内脏血流重新分布。总体效应α优势，肾脏血流减少，冠状血管血流增加。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肾上腺素：最古老、最有效、适用于各型心跳骤停，为心肺复苏的王牌用药。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
术后严重低心排， 0.01～0.3ug/kg.min 。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
局部缩血管作用：气管插管内出血、喉头水肿喷雾。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肌体代谢增强，心脏氧耗增加，不易长期应用。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
易造成心律失常。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肾脏血流减少，加强监测。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
对低心派严重者，应积极寻找更有效的治疗手段，如：二次手术、机械辅助等。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
异丙肾上腺素（isoprenaline）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
选择性1-R、2-R兴奋剂（1＞2）。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
加快心率及传导速度。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
多用于HR不快的低排患儿，心律失常的副作用小于副肾。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肺高压患儿，舒张支气管、血管平滑肌。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
去甲肾上腺素（noradrenaline）药理作用Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
强烈的-R兴奋作用，除冠脉外，几乎所有的小动脉和小静脉都表现出强烈的收缩作用。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
对冠脉的扩张可能与心肌代谢产物腺苷明显增加有关。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
去甲肾上腺素（noradrenaline） 在 PICU应用Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
感染性休克时，为增加外周阻力，有很强的应用指征，即使合并心功能不全，严密监测下也可应用。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
上消化道出血时可应用。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
酚妥拉明phentolamine （regitine)Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
短效-R阻断剂，扩张动静脉Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
顽固高血压合并肺高压患儿可选用。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
如：弓中断，弓缩窄。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
普萘洛儿（心得安，propranolol）：对梗阻性心脏病患儿，增加心室舒张顺应性，减少术前缺氧发作。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
艾斯洛尔：短效，多应用于术后快速性心律失常。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
氨酰心安：口服长效，可应用于儿茶酚胺水平过高的高动力型先心病术后，如心率快合并高血压者。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
地高辛药理作用Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
与细胞膜上的Na-K-ATP酶结合--抑制Na-K交换--心肌细胞内Ca增多--心肌收缩增强Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
治疗剂量可增强心肌收缩力，缩短心动周期中的收缩期。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
同时反射性的降低交感张力，减慢心率。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
地高辛在PICUKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
早年应用多。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
但由于其起效慢，有效剂量接近中毒剂量，影响因素多（低钾、低镁、高钙、缺氧、酸中毒等），现在只将其作为辅助用药和后期用药。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
氨力农（amrinone）和米力农（milrinone）药理作用Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
通过抑制心肌磷酸二酯酶（PDG）--增加心肌及血管平滑肌细胞内cAMP含量--增加心肌收缩力，且不影响HR。降低体、肺血管阻力。心肌氧耗减低。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
氨力农（amrinone）和米力农（milrinone）在PICUKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
有人推荐用于儿茶酚胺耐受的心衰病人。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
PICU内常用于希望同时强心并减低血管阻力，改善末梢组织灌注者，如乳酸增高患儿。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肺高压，降低肺循环阻力，同时维护右心功能。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
其扩血管作用往往引起临床应用的顾虑，该作用与剂量呈正相关性，剂量的把握和及时补足容量是关键。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
血小板减少、肝功能损害，应加强监测。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝酸甘油（nitroglycerin）Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
扩张静脉和冠状动脉，降压不明显。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
PICU内应用：Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
①减低心脏前负荷，同时扩张冠脉，改善心肌灌注和心肌作功状态。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
②对于手术与冠脉相关的病人常规应用。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
③高血压的治疗效果不满意。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
硝普钠（sodium nitroprusside）强有效的血管扩张药物，同时作用在小动、静脉。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
近年来的研究认为是通过增加NO的含量而直接扩张血管平滑肌Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
PICU内高血压患儿的首选用药，血容量不足者要缓慢增加剂量。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
大剂量超过3天可引起硫氰化物中毒，病情稳定后可口服开搏通。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
心血管用药对重要器官的影响Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
心脏：冠脉血流由心肌本身的代谢水平决定。体循环舒张压高，冠脉血增多。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肺脏：氧、二氧化碳、PH，交感神经兴奋、儿茶酚胺类药物，使体循环血管收缩，肺循环血容量增加。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
脑：自身调节机制维持其血流的恒定性。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肾脏：除自身调节机制外，儿茶酚胺类药物使肾血流减少。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肾上腺皮质激素药理作用Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
生理作用：调节糖代谢。抗炎，降低毛细血管的通透性、减少渗出。稳定细胞溶酶体和线粒体，减轻细胞损伤。增加肾上腺素受体的表达，中度升高血压。对抗创伤、感染、恐惧等应激反应。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
肾上腺皮质激素在PICUKjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
术后早期：转机时间长，减轻心肌水肿。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
有渗漏体质者：减少渗出。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
心率失常者：减轻传导系统的水肿。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
拔管前后：减轻喉头水肿。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
重症感染者：在足量、有效抗生素保驾下，利用其抗炎和抗应激作用。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
中枢神经系统并发症：减轻脑水肿。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
副作用：组织愈合不良，消化道出血，免疫抑制。Kjk胸部肿瘤防治工作组 Thoracic Cancer Cooperative Groups
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