工程建设焊接协会:KEGG PATHWAY: Wnt signaling pathway - Referen...

   Wnt signaling pathway - Reference pathway
[Pathway menu |Pathway entry |Show description ] Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Reference pathway Reference pathway (KO) -----< Set personalized menu >----- -----< Sort below by alphabet >----- Homo sapiens (human) Pan troglodytes (chimpanzee) Macaca mulatta (rhesus monkey) Mus musculus (mouse) Rattus norvegicus (rat) Canis familiaris (dog) Bos taurus (cow) Sus scrofa (pig) Equus caballus (horse) Monodelphis domestica (opossum) Ornithorhynchus anatinus (platypus) Gallus gallus (chicken) Taeniopygia guttata (zebra finch) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Danio rerio (zebrafish) Branchiostoma floridae (Florida lancelet) Ciona intestinalis (sea squirt) Strongylocentrotus purpuratus (purple sea urchin) Drosophila melanogaster (fruit fly) Drosophila pseudoobscura pseudoobscura Drosophila ananassae Drosophila erecta Drosophila persimilis Drosophila sechellia Drosophila simulans Drosophila yakuba Drosophila grimshawi Drosophila mojavensis Anopheles gambiae (mosquito) Aedes aegypti (yellow fever mosquito) Culex quinquefasciatus (southern house mosquito) Apis mellifera (honey bee) Nasonia vitripennis (jewel wasp) Tribolium castaneum (red flour beetle) Acyrthosiphon pisum (pea aphid) Caenorhabditis elegans (nematode) Caenorhabditis briggsae Brugia malayi (filaria) Schistosoma mansoni Nematostella vectensis (sea anemone) Hydra magnipapillata Trichoplax adhaerens